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Molecular Profile | RET positive |
Therapy | Y078-DM4 |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET positive | breast cancer | sensitive | Y078-DM4 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Y078-DM4 induced cytotoxicity in RET-expressing human breast cancer cell lines in culture and inhibited tumor growth in xenograft models (PMID: 26240273). | 26240273 |
PubMed Id | Reference Title | Details |
---|---|---|
(26240273) | Preclinical Efficacy and Safety Assessment of an Antibody-Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma. | Full reference... |