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| Molecular Profile | RET over exp |
| Therapy | Y078-DM1 |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET over exp | breast cancer | sensitive | Y078-DM1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Y078-DM1 induced cytotoxicity in a human breast cancer cell line with high levels of RET expression in culture and inhibited tumor growth in xenograft models (PMID: 26240273). | 26240273 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26240273) | Preclinical Efficacy and Safety Assessment of an Antibody-Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma. | Full reference... |