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| Molecular Profile | SMARCB1 negative |
| Therapy | DZNeP + Radiotherapy |
| Indication/Tumor Type | atypical teratoid rhabdoid tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCB1 negative | atypical teratoid rhabdoid tumor | sensitive | DZNeP + Radiotherapy | Preclinical | Actionable | In a preclinical study, DZNep increased radiosensitivity in SMARCB1-negative atypical teratoid rhabdoid tumor cell lines in culture (PMID: 23190500). | 23190500 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23190500) | Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells. | Full reference... |