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Molecular Profile | MLH1 inact mut |
Therapy | N/A |
Indication/Tumor Type | colorectal cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MLH1 inact mut | colorectal cancer | not applicable | N/A | Preclinical | Emerging | In a preclinical study, MLH1 inactivation through hypermethylation was associated with high microsatellite instability (MSI-H) colorectal carcinoma by whole genome sequencing of tumor samples (PMID: 22810696), suggesting it may be a potential biomarker. | 22810696 |
PubMed Id | Reference Title | Details |
---|---|---|
(22810696) | Comprehensive molecular characterization of human colon and rectal cancer. | Full reference... |