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Molecular Profile | TP53 mutant |
Therapy | PD0166285 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 mutant | colorectal cancer | sensitive | PD0166285 | Preclinical | Actionable | In a preclinical study, PD0166285 sensitizes colorectal cancer cells with TP53 mutation to radiation induced cell death (PMID: 11719452). | 11719452 |
PubMed Id | Reference Title | Details |
---|---|---|
(11719452) | Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. | Full reference... |