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Molecular Profile | PTEN loss |
Therapy | KX2-391 |
Indication/Tumor Type | ovarian mucinous neoplasm |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | ovarian mucinous neoplasm | decreased response | KX2-391 | Preclinical | Actionable | In a preclincal study, mucinous ovarian carcinoma cell lines harboring PTEN loss were less sensitive to KX2-391 induced growth inhibition in culture and tumor suppression in xenograft models (PMID: 24100628). | 24100628 |
PubMed Id | Reference Title | Details |
---|---|---|
(24100628) | Targeting SRC and tubulin in mucinous ovarian carcinoma. | Full reference... |