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| Molecular Profile | FLT3 amp |
| Therapy | Sorafenib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 amp | colorectal cancer | predicted - sensitive | Sorafenib | Case Reports/Case Series | Actionable | In a clinical case study, Nexavar (sorafenib) treatment targeting FLT3 amplification in a rectal adenocarcinoma patient who had progressed on all standard therapies resulted in rapid clinical improvement (PMID: 25848357). | 25848357 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25848357) | Clinical Response to Sorafenib in a Patient with Metastatic Colorectal Cancer and FLT3 Amplification. | Full reference... |