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Molecular Profile | MSH6 mutant |
Therapy | N/A |
Indication/Tumor Type | colorectal cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH6 mutant | colorectal cancer | not applicable | N/A | Clinical Study | Diagnostic | Germline mutations in MSH6 are associated with microsatellite instability in colorectal cancer (CRC), and are diagnostic for Lynch syndrome (hereditary nonpolyposis colorectal cancer) in colorectal cancer patients (PMID: 26582061; PMID: 19125127). | 26582061 19125127 |
PubMed Id | Reference Title | Details |
---|---|---|
(26582061) | Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer. | Full reference... |
(19125127) | EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. | Full reference... |