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| Molecular Profile | MSH6 mutant |
| Therapy | N/A |
| Indication/Tumor Type | colorectal cancer |
| Response Type | not applicable |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH6 mutant | colorectal cancer | not applicable | N/A | Clinical Study | Diagnostic | Germline mutations in MSH6 are associated with microsatellite instability in colorectal cancer (CRC), and are diagnostic for Lynch syndrome (hereditary nonpolyposis colorectal cancer) in colorectal cancer patients (PMID: 26582061; PMID: 19125127). | 26582061 19125127 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26582061) | Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer. | Full reference... |
| (19125127) | EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. | Full reference... |