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Molecular Profile | PIK3CA R88Q |
Therapy | Apitolisib |
Indication/Tumor Type | malignant pleural mesothelioma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA R88Q | malignant pleural mesothelioma | predicted - sensitive | Apitolisib | Case Reports/Case Series | Actionable | In a Phase I trial, treatment with Apitolisib (GDC-0980) resulted in a partial response in a patient with malignant pleural mesothelioma harboring PIK3CA R88Q (PMID: 26787751; NCT00854152). | 26787751 |
PubMed Id | Reference Title | Details |
---|---|---|
(26787751) | Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors. | Full reference... |