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| Molecular Profile | RET C634R |
| Therapy | Pz-1 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634R | Advanced Solid Tumor | sensitive | Pz-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Pz-1 inhibited Ret signaling in transformed cells over expressing RET C634R and inhibited tumor growth in cell line xenografts models (PMID: 26126987). | 26126987 |
| RET C634R | Advanced Solid Tumor | sensitive | Pz-1 | Preclinical - Cell culture | Actionable | In a preclinical study, Pz-1 treatment inhibited Ret phosphorylation and growth of transformed cells expressing RET C634R in culture (PMID: 34373541). | 34373541 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26126987) | Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. | Full reference... |
| (34373541) | Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases. | Full reference... |