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Molecular Profile | RET M918T |
Therapy | Pz-1 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET M918T | Advanced Solid Tumor | sensitive | Pz-1 | Preclinical - Cell culture | Actionable | In a preclinical study, Pz-1 treatment inhibited Ret phosphorylation and growth of transformed cells expressing RET M918T in culture (PMID: 34373541). | 34373541 |
RET M918T | Advanced Solid Tumor | sensitive | Pz-1 | Preclinical | Actionable | In a preclinical study, Pz-1 inhibited Ret phosphorylation in transformed cells expressing RET M918T (PMID: 26126987). | 26126987 |
PubMed Id | Reference Title | Details |
---|---|---|
(26126987) | Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. | Full reference... |
(34373541) | Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases. | Full reference... |