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| Molecular Profile | EML4 - ALK |
| Therapy | Ceritinib |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | lung non-small cell carcinoma | sensitive | Ceritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Zykadia (ceritinib) inhibited phosphorylation of Alk and inhibited growth of human non-small cell lung cancer cell lines harboring EML4-ALK in culture (PMID: 25173427). | 25173427 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25173427) | Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer. | Full reference... |