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Molecular Profile | EML4 - ALK |
Therapy | Alectinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK | lung non-small cell carcinoma | sensitive | Alectinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Alecensa (alectinib) inhibited Alk phosphorylation and growth of a human non-small cell lung cancer cell line harboring EML4-ALK in culture and in cell line xenograft models (PMID: 21575866). | 21575866 |
PubMed Id | Reference Title | Details |
---|---|---|
(21575866) | CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. | Full reference... |