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Molecular Profile | CBL dec exp |
Therapy | Erlotinib + Gemcitabine |
Indication/Tumor Type | pancreatic ductal carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CBL dec exp | pancreatic ductal carcinoma | predicted - sensitive | Erlotinib + Gemcitabine | Preclinical - Cell line xenograft | Emerging | In a preclinical study, addition of Tarceva (erlotinib) overcame Gemzar (gemcitabine)-resistance in pancreatic ductal carcinoma cell lines with reduced Cbl expression via shRNA, resulted in decreased viability in cell culture and reduced tumor growth in cell line xenograft models (PMID: 25348515). | 25348515 |
PubMed Id | Reference Title | Details |
---|---|---|
(25348515) | Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition. | Full reference... |