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| Molecular Profile | CSF3R mutant |
| Therapy | N/A |
| Indication/Tumor Type | bone marrow cancer |
| Response Type | not applicable |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CSF3R mutant | bone marrow cancer | not applicable | N/A | Clinical Study | Emerging | In clinical studies, high frequency of CSF3R mutations was identified in patients with chronic neutrophilic leukemia (PMID: 23656643, PMID: 24081659), suggesting that this may serve as a future diagnostic biomarker (PMID: 24441292). | 24081659 23656643 24441292 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23656643) | Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. | Full reference... |
| (24081659) | The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. | Full reference... |
| (24441292) | An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms. | Full reference... |