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Molecular Profile BRAF V600E
Therapy Trametinib + Vemurafenib
Indication/Tumor Type neuroendocrine tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E neuroendocrine tumor predicted - sensitive Trametinib + Vemurafenib Case Reports/Case Series Actionable In a clinical case study, Mekinist (trametinib) and Zelboraf (vemurafenib) combination treatment resulted in a rapid and sustained clinical response in a patient with a rectal neuroendocrine tumor harboring a BRAF V600E mutation (PMID: 27048246). 27048246
PubMed Id Reference Title Details
(27048246) BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Full reference...