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| Molecular Profile | KIT V654A |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V654A | Advanced Solid Tumor | resistant | Imatinib | Preclinical | Actionable | In a preclinical study, cells expressing KIT V654A demonstrated resistance to Gleevec (imatinib) in culture (PMID: 16751810). | 16751810 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (16751810) | Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients. | Full reference... |