Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | KIT V654A |
Therapy | Imatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V654A | Advanced Solid Tumor | resistant | Imatinib | Preclinical | Actionable | In a preclinical study, cells expressing KIT V654A demonstrated resistance to Gleevec (imatinib) in culture (PMID: 16751810). | 16751810 |
PubMed Id | Reference Title | Details |
---|---|---|
(16751810) | Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients. | Full reference... |