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| Molecular Profile | KIT Y553N |
| Therapy | Imatinib |
| Indication/Tumor Type | thymic carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT Y553N | thymic carcinoma | sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with metastatic thymic carcinoma harboring KIT Y553N demonstrated improved clinical performance and reduction in metastatic lesions following treatment with Gleevec (imatinib) (PMID: 21969494). | 21969494 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21969494) | Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma. | Full reference... |