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Molecular Profile | KIT V560del KIT over exp |
Therapy | Imatinib |
Indication/Tumor Type | thymic carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560del KIT over exp | thymic carcinoma | predicted - sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case report, a patient with metastatic thymic carcinoma harboring KIT V560del with KIT over expression initially demonstrated stable disease and reduction in metastatic lesions following treatment with Gleevec (imatinib), but progressed after 6 months (PMID: 15201427). | 15201427 |
PubMed Id | Reference Title | Details |
---|---|---|
(15201427) | Thymic carcinoma with overexpression of mutated KIT and the response to imatinib. | Full reference... |