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| Molecular Profile | BRAF T529M BRAF V600E |
| Therapy | CI-1040 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF T529M BRAF V600E | Advanced Solid Tumor | predicted - sensitive | CI-1040 | Preclinical | Actionable | In a preclinical study, CI-1040 (PD184352) inhibited Erk phosphorylation in transformed cells expressing BRAF V600E and the gatekeeper mutation BRAF T529M in culture (PMID: 20538618). | 20538618 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20538618) | Gatekeeper mutations mediate resistance to BRAF-targeted therapies. | Full reference... |