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| Molecular Profile | FGFR1 amp |
| Therapy | Fexagratinib |
| Indication/Tumor Type | lung large cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 amp | lung large cell carcinoma | sensitive | Fexagratinib | Preclinical | Actionable | In a preclinical study, Fexagratinib (AZD4547) inhibited proliferation of a large cell lung cancer cell line harboring FGFR1 amplification in culture and induced tumor regression in xenograft models (PMID: 23082000). | 23082000 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23082000) | Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. | Full reference... |