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Molecular Profile | FGFR1 wild-type |
Therapy | Fexagratinib |
Indication/Tumor Type | lung cancer |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 wild-type | lung cancer | decreased response | Fexagratinib | Preclinical | Actionable | In a preclinical study, FGFR1 non-amplified lung cancer cell lines demonstrated reduced sensitivity to AZD4547 induced growth inhibition in culture and in xenograft models (PMID: 23082000). | 23082000 |
PubMed Id | Reference Title | Details |
---|---|---|
(23082000) | Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. | Full reference... |