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| Molecular Profile | KIT W557G |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT W557G | Advanced Solid Tumor | sensitive | Imatinib | Preclinical | Actionable | In a preclinical study, Gleevec (imatinib mesylate) inhibited Kit phosphorylation efficiently in transformed human cells over expressing KIT W557G in culture (PMID: 23567324). | 23567324 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23567324) | Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib. | Full reference... |