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Molecular Profile | BRAF V600E MAP2K1 H119P |
Therapy | Selumetinib |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E MAP2K1 H119P | melanoma | resistant | Selumetinib | Preclinical | Actionable | In a preclinical study, expression of MAP2K1 H119P in melanoma cells harboring BRAF V600E conferred resistance to Koselugo (selumetinib) treatment in culture (PMID: 19915144). | 19915144 |
PubMed Id | Reference Title | Details |
---|---|---|
(19915144) | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | Full reference... |