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| Molecular Profile | BRAF V600E MAP2K1 C121S |
| Therapy | VX-11e |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E MAP2K1 C121S | melanoma | sensitive | VX-11e | Preclinical | Actionable | In a preclinical study, melanoma cells harboring BRAF V600E and expressing MAP2K1 C121S demonstrated sensitivity to treatment with VX-11e, resulting in decreased cell growth in culture (PMID: 24265153). | 24265153 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24265153) | The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. | Full reference... |