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Molecular Profile BRAF V600E MAP2K1 G128V
Therapy Dabrafenib + Trametinib
Indication/Tumor Type melanoma
Response Type conflicting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E MAP2K1 G128V melanoma conflicting Dabrafenib + Trametinib Preclinical Actionable In a preclinical study, MAP2K1 G128V conferred resistance to the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) in BRAF V600E-mutant melanoma cells in culture (PMID: 24265154). 24265154
BRAF V600E MAP2K1 G128V melanoma conflicting Dabrafenib + Trametinib Preclinical - Cell culture Actionable In a preclinical study, the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) synergistically inhibited viability of a melanoma cell line harboring BRAF V600E and expressing MAP2K1 G128V in culture (PMID: 36442478). 36442478
PubMed Id Reference Title Details
(24265154) MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Full reference...
(36442478) High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer. Full reference...