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Molecular Profile | BRAF V600E MAP2K1 C121S |
Therapy | PLX4720 |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E MAP2K1 C121S | melanoma | resistant | PLX4720 | Preclinical | Actionable | In a preclinical study, expression of MAP2K1 C121S conferred resistance to PLX4720 in melanoma cells harboring BRAF V600E in culture (PMID: 21383288). | 21383288 |
PubMed Id | Reference Title | Details |
---|---|---|
(21383288) | Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. | Full reference... |