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| Molecular Profile | BRAF V600E PTEN loss |
| Therapy | Pictilisib + PLX4720 |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E PTEN loss | melanoma | sensitive | Pictilisib + PLX4720 | Preclinical | Actionable | In a preclinical study, a melanoma cell line harboring BRAF V600E and PTEN loss demonstrated sensitivity when treated with a combination of Pictilisib (GDC-0941) and PLX4720, resulting in decreased cell proliferation in culture (PMID: 24265153). | 24265153 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24265153) | The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. | Full reference... |