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| Molecular Profile | SRC positive |
| Therapy | Si306 |
| Indication/Tumor Type | glioblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SRC positive | glioblastoma | sensitive | Si306 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Si306 inhibited SRC phosphorylation and proliferation of SRC-expressing glioblastoma cell lines in culture, and inhibited tumor growth and increased survival in cell line xenograft models (PMID: 27196762). | 27196762 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27196762) | Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells. | Full reference... |