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Molecular Profile | ABL1 R332W |
Therapy | Imatinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ABL1 R332W | lung adenocarcinoma | sensitive | Imatinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Gleevec (imatinib) inhibited growth of a lung adenocarcinoma cell line harboring ABL1 R332W (also reported as R351W) in culture, and inhibited tumor growth in xenograft models (PMID: 26758680). | 26758680 |
PubMed Id | Reference Title | Details |
---|---|---|
(26758680) | Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. | Full reference... |