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Molecular Profile | ABL1 T315I ABL1 R332W |
Therapy | Imatinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ABL1 T315I ABL1 R332W | lung adenocarcinoma | resistant | Imatinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, lung adenocarcinoma cells harboring ABL1 R332W (also reported as R351W) and expressing ABL1 T315I demonstrated resistance to Gleevec (imatinib) in culture and in xenograft models (PMID: 26758680). | 26758680 |
PubMed Id | Reference Title | Details |
---|---|---|
(26758680) | Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. | Full reference... |