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Molecular Profile | ABL1 G321L |
Therapy | Dasatinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ABL1 G321L | lung adenocarcinoma | sensitive | Dasatinib | Preclinical | Actionable | In a preclinical study, treatment with Sprycel (dasatinib) in decreased CRKL phosphorylation and reduced viability of lung adenocarcinoma cells harboring ABL1 G321L (also reported as G340L) in culture (PMID: 26758680). | 26758680 |
PubMed Id | Reference Title | Details |
---|---|---|
(26758680) | Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. | Full reference... |