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Molecular Profile | JAK1 Y654F |
Therapy | Pyridone 6 |
Indication/Tumor Type | Sezary's disease |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK1 Y654F | Sezary's disease | sensitive | Pyridone 6 | Preclinical - Cell culture | Actionable | In a preclinical study, Pyridone 6 (CMP6) inhibited proliferation of cells derived from a Sezary syndrome patient harboring JAK1 Y654F in culture (PMID: 26415585). | 26415585 |
PubMed Id | Reference Title | Details |
---|---|---|
(26415585) | Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sézary syndrome. | Full reference... |