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| Molecular Profile | JAK3 V674A |
| Therapy | NIBR3049 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK3 V674A | Advanced Solid Tumor | decreased response | NIBR3049 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells over expressing JAK3 V674A demonstrated reduced sensitivity to NIBR3049 in culture (PMID: 26446793). | 26446793 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26446793) | Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities. | Full reference... |