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Molecular Profile | JAK2 V617F |
Therapy | SHP099 |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | hematologic cancer | sensitive | SHP099 | Preclinical - Cell culture | Actionable | In a preclinical study, SHP099 inhibited proliferation of a hematopoietic cancer cell line harboring JAK2 V617F in culture (PMID: 27362227). | 27362227 |
PubMed Id | Reference Title | Details |
---|---|---|
(27362227) | Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. | Full reference... |