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| Molecular Profile | FLT3 exon 14 ins |
| Therapy | SHP099 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | predicted - sensitive | SHP099 | Preclinical - Pdx | Actionable | In a preclinical study, treatment with SHP099 resulted in reduction of CD45-positive leukemic cells and decreased splenomegaly in a human primary tumor-derived xenograft model of acute myeloid leukemia harboring a FLT3-ITD mutation (PMID: 27362227). | 27362227 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27362227) | Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. | Full reference... |