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| Molecular Profile | BRAF V600E |
| Therapy | SHP099 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colorectal cancer | resistant | SHP099 | Preclinical - Cell culture | Actionable | In a preclincial study, colorectal cancer cell lines harboring BRAF V600E demonstrated resistance to SHP099 in culture (PMID: 27362227). | 27362227 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27362227) | Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. | Full reference... |