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Molecular Profile FGFR1 amp
Therapy Fexagratinib
Indication/Tumor Type breast cancer
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 amp breast cancer no benefit Fexagratinib Phase II Actionable In a Phase II clinical trial, treatment with AZD4547 resulted in a response rate of 12.5% (1/8) in patients with FGFR1-amplified breast cancer, and did not meet the predetermined criteria for efficacy (PMID: 27179038). 27179038
PubMed Id Reference Title Details
(27179038) High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. Full reference...