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| Molecular Profile | FGFR1 amp |
| Therapy | Fexagratinib |
| Indication/Tumor Type | breast cancer |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 amp | breast cancer | no benefit | Fexagratinib | Phase II | Actionable | In a Phase II clinical trial, treatment with Fexagratinib (AZD4547) resulted in a response rate of 12.5% (1/8) in patients with FGFR1-amplified breast cancer, and did not meet the predetermined criteria for efficacy (PMID: 27179038). | 27179038 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27179038) | High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. | Full reference... |