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Molecular Profile | BRAF V600K MAP2K1 P124L |
Therapy | Trametinib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600K MAP2K1 P124L | melanoma | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, Mekinist (trametinib) inhibited ERK signaling and reduced growth of a melanoma cell line harboring BRAF V600K and MAP2K1 P124L in culture (PMID: 25370473). | 25370473 |
PubMed Id | Reference Title | Details |
---|---|---|
(25370473) | Preexisting MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients. | Full reference... |