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| Molecular Profile | ERBB4 G1109C |
| Therapy | Cetuximab |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB4 G1109C | head and neck squamous cell carcinoma | no benefit | Cetuximab | Preclinical - Cell culture | Actionable | In a preclinical study, head and neck squamous cell carcinoma cells harboring ERBB4 (HER4) G1109C were insensitive to treatment with Erbitux (cetuximab) in culture (PMID: 27207775). | 27207775 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27207775) | Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC. | Full reference... |