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Molecular Profile | BRAF V600E |
Therapy | PLX4720 |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | colon cancer | sensitive | PLX4720 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PLX4720 inhibited growth of colon cancer cells harboring BRAF V600E in culture and in cell line xenograft models (PMID: 18287029). | 18287029 |
PubMed Id | Reference Title | Details |
---|---|---|
(18287029) | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. | Full reference... |