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Molecular Profile | IDH2 D76fs |
Therapy | Venetoclax |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH2 D76fs | acute myeloid leukemia | sensitive | Venetoclax | Case Reports/Case Series | Actionable | In a Phase II trial, an acute myeloid leukemia patient harboring IDH2 D76fs demonstrated sensitivity to treatment with Venclexta (venetoclax), achieving a complete response with incomplete blood count recovery after 24 weeks (PMID: 27520294). | 27520294 |
PubMed Id | Reference Title | Details |
---|---|---|
(27520294) | Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia. | Full reference... |