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Molecular Profile | TP53 V173M |
Therapy | APR-246 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 V173M | acute myeloid leukemia | predicted - sensitive | APR-246 | Case Reports/Case Series | Actionable | In a Phase I trial, APR-246 demonstrated safety and preliminary clinical activity in patients with hematological cancers, including an acute myeloid leukemia patient harboring TP53 V173M that achieved a decrease in bone marrow blast percentage from 46% to 26% (PMID: 22965953). | 22965953 |
PubMed Id | Reference Title | Details |
---|---|---|
(22965953) | Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. | Full reference... |