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| Molecular Profile | ARID1A mutant |
| Therapy | Dasatinib |
| Indication/Tumor Type | ovarian clear cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ARID1A mutant | ovarian clear cell carcinoma | sensitive | Dasatinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Sprycel (dasatinib) resulted in decreased cell growth of ovarian clear cell carcinoma (OCCC) cells harboring an ARID1A mutation in culture and anti-tumor activity in cell line xenograft models of OCCC (PMID: 27364904). | 27364904 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27364904) | Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. | Full reference... |