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Molecular Profile | BRAF V600X PTEN neg |
Therapy | Uprosertib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600X PTEN neg | melanoma | sensitive | Uprosertib | Preclinical - Cell culture | Actionable | In a preclinical study, lack of PTEN expression was associated with increased sensitivity to GSK2141795 in BRAF V600-mutant melanoma cell lines in culture (PMID: 24265152). | 24265152 |
PubMed Id | Reference Title | Details |
---|---|---|
(24265152) | A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition. | Full reference... |