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Molecular Profile | TP53 loss |
Therapy | KRT-232 + Radiotherapy |
Indication/Tumor Type | lung cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | lung cancer | resistant | KRT-232 + Radiotherapy | Preclinical - Cell line xenograft | Actionable | In a preclinical study, KRT-232 (AMG 232) did not enhance radiation-induced cytotoxicity in TP53-null lung cancer cells in culture and in cell line xenograft models (PMID: 26162687). | 26162687 |
PubMed Id | Reference Title | Details |
---|---|---|
(26162687) | Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors. | Full reference... |