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Molecular Profile | TP53 R248W VHL inact mut |
Therapy | PT2399 |
Indication/Tumor Type | clear cell renal cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R248W VHL inact mut | clear cell renal cell carcinoma | resistant | PT2399 | Preclinical - Cell culture | Actionable | In a preclinical study, TP53 R248W was associated with resistance to PT2399 in VHL-defective clear cell renal cell carcinoma cell lines in culture (PMID: 27595393). | 27595393 |
PubMed Id | Reference Title | Details |
---|---|---|
(27595393) | On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. | Full reference... |