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| Molecular Profile | TP53 R273H TP53 P309S |
| Therapy | Cisplatin + NSC59984 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R273H TP53 P309S | colorectal cancer | sensitive | Cisplatin + NSC59984 | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of Platinol (cisplatin) and NSC59984 worked synergistically to decrease viability of a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215). | 26294215 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26294215) | Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. | Full reference... |