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Molecular Profile | CHEK1 positive |
Therapy | CCT244747 + Radiotherapy |
Indication/Tumor Type | head and neck squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CHEK1 positive | head and neck squamous cell carcinoma | sensitive | CCT244747 + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, CCT244747 inhibited Chek1 activation, resulted in sensitizing head and neck squamous cell carcinoma cell lines to radiation treatment in culture (PMID: 27422809). | 27422809 |
PubMed Id | Reference Title | Details |
---|---|---|
(27422809) | CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy. | Full reference... |