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Molecular Profile | PIK3CA mutant |
Therapy | PF-04691502 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | lung non-small cell carcinoma | sensitive | PF-04691502 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PF-04691502 inhibited tumor growth in non-small cell lung cancer cell line xenograft models harboring PIK3CA mutations (PMID: 21750219). | 21750219 |
PubMed Id | Reference Title | Details |
---|---|---|
(21750219) | PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. | Full reference... |